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  • Metabolism of hydroxyproline and synthesis of oxalic acid in
  • 文章来源:365bet平台怎么样Date:2019-02-20 13:42 Click:

Background: endogenous oxalate synthesis promotes the development of calcium oxalate stones in patients with hereditary primary hyperoxaluria (PH). Inadequate knowledge of oxalate synthesis has made the discovery of new therapies difficult. Hydroxyproline (Hyp) is metabolized to produce oxalate and glycolate. However, the relative role of Hyp metabolism in the synthesis of endogenous oxalate and glycolic acid remains unclear.

Methods: to clarify this effect, we performed continuous intravenous infusion of stable isotopes [15N, 13C5] -hyp in 9 healthy subjects and 19 PH patients, and measured urinary 13c2-oxalic acid and 13c2-glycolic acid levels by ion chromatography combined with quality testing.


Results: the urinary oxalate/ creatinine ratios were 73.1, 70.8, 47.0 and 10.6 mg oxalate/g creatnine for PH1, PH2, PH3 and control groups during injection. Compared with the control group's Hyp metabolic level of 1.6 mg oxalate/g creatinine, the Hyp metabolic levels in the PH1, PH2 and PH3 groups were 12.8 mg oxalate/g creatnine, 32.9 and 14.8 mg oxalate/g creatnine, respectively. The effect of Hyp on urinary oxalate was 15% in the control group, 18% in PH1, 47% in PH2 and 33% in PH3. The effect of Hyp on urine glycolic acid was 57% in control group, 30% in PH1 group, and 13% in PH2 or PH3 patients.

Conclusion: Hyp metabolism is different in different PH types, and Hyp metabolism is the main source of oxalic acid synthesis in PH2 and PH3 individuals. The source of oxalate in PH1 patients with the highest urinary oxalate excretion remains to be determined.

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